Synchrony dynamics during initiation, failure, and rescue of the segmentation clock

Ingmar H. Riedel-Kruse, Claudia Müller, Andrew C. Oates

Research output: Contribution to journalArticlepeer-review

204 Scopus citations

Abstract

The "segmentation clock" is thought to coordinate sequential segmentation of the body axis in vertebrate embryos. This clock comprises a multicellular genetic network of synchronized oscillators, coupled by intercellular Delta-Notch signaling. How this synchrony is established and how its loss determines the position of segmentation defects in Delta and Notch mutants are unknown. We analyzed the clock's synchrony dynamics by varying strength and timing of Notch coupling in zebrafish embryos with techniques for quantitative perturbation of gene function. We developed a physical theory based on coupled phase oscillators explaining the observed onset and rescue of segmentation defects, the clock's robustness against developmental noise, and a critical point beyond which synchrony decays. We conclude that synchrony among these genetic oscillators can be established by simultaneous initiation and self-organization and that the segmentation defect position is determined by the difference between coupling strength and noise.

Original languageEnglish (US)
Pages (from-to)1911-1915
Number of pages5
JournalScience
Volume317
Issue number5846
DOIs
StatePublished - Sep 28 2007
Externally publishedYes

ASJC Scopus subject areas

  • General

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