TY - JOUR
T1 - Symptoms of attention-deficit/hyperactivity disorder in down syndrome
T2 - Effects of the dopamine receptor D4 gene
AU - Mason, Gina Marie
AU - Spanó, Goffredina
AU - Edgin, Jamie
N1 - Publisher Copyright:
© AAIDD.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - This study examined individual differences in ADHD symptoms and executive function (EF) in children with Down syndrome (DS) in relation to the dopamine receptor D4 (DRD4) gene, a gene often linked to ADHD in people without DS. Participants included 68 individuals with DS (7-21 years), assessed through laboratory tasks, caregiver reports, and experimenter ratings. Saliva samples were collected from the DS group and 66 children without DS to compare DRD4 allele distribution, showing no difference between the groups. When the sample with DS was stratified for ethnicity (n = 32), the DRD4 7-repeat allele significantly related to parent and experimenter ratings, but not to laboratory assessments. These results suggest that nontrisomy genetic factors may contribute to individual differences in ADHD symptoms in persons with DS.
AB - This study examined individual differences in ADHD symptoms and executive function (EF) in children with Down syndrome (DS) in relation to the dopamine receptor D4 (DRD4) gene, a gene often linked to ADHD in people without DS. Participants included 68 individuals with DS (7-21 years), assessed through laboratory tasks, caregiver reports, and experimenter ratings. Saliva samples were collected from the DS group and 66 children without DS to compare DRD4 allele distribution, showing no difference between the groups. When the sample with DS was stratified for ethnicity (n = 32), the DRD4 7-repeat allele significantly related to parent and experimenter ratings, but not to laboratory assessments. These results suggest that nontrisomy genetic factors may contribute to individual differences in ADHD symptoms in persons with DS.
KW - Attention-deficit/hyperactivity disorder
KW - Cognitive assessment
KW - Dopamine
KW - Down syndrome
KW - Executive function
KW - Intellectual disabilities
KW - Trisomy 21
UR - http://www.scopus.com/inward/record.url?scp=84920378570&partnerID=8YFLogxK
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U2 - 10.1352/1944-7558-120.1.58
DO - 10.1352/1944-7558-120.1.58
M3 - Article
C2 - 25551267
AN - SCOPUS:84920378570
SN - 1944-7515
VL - 120
SP - 58
EP - 71
JO - American Journal on Intellectual and Developmental Disabilities
JF - American Journal on Intellectual and Developmental Disabilities
IS - 1
ER -