Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy

Blanca Noriega Esquives, Tae K. Lee, Patricia I. Moreno, Rina S. Fox, Betina Yanez, Gregory E. Miller, Ryne Estabrook, Mark J. Begale, Sarah C. Flury, Kent Perry, Shilajit D. Kundu, Frank J. Penedo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


To identify symptom burden profiles among men with advanced prostate cancer undergoing androgen-deprivation therapy and examine their association with baseline sociodemographic and medical characteristics and psychosocial outcomes over time. Latent profile analysis was employed to identify distinct groups based on the Expanded Prostate Index Composite and the McGill Pain Questionnaire at baseline. Psychosocial outcomes were assessed at baseline, 6- and 12-month follow-ups. Three profiles emerged: “high symptom burden,” “high sexual bother,” and “low symptom burden.” Men with “high symptom burden” were younger and exhibited higher baseline levels of depression, stress, cancer-specific distress, and anxiety than men in the other two groups. However, men with “high symptom burden” also demonstrated improvement in these psychosocial outcomes over time. Men with advanced prostate cancer who experience multiple co-occurring symptoms demonstrate worse psychosocial adjustment. Patients with substantial symptom burden, and specifically young men, may benefit from prompt referral to supportive care services.

Original languageEnglish (US)
Pages (from-to)366-377
Number of pages12
JournalJournal of Behavioral Medicine
Issue number3
StatePublished - Jun 2022
Externally publishedYes


  • Androgen deprivation therapy
  • Latent profile analysis
  • Prostate cancer
  • Psychosocial well-being
  • Quality of life
  • Symptom burden

ASJC Scopus subject areas

  • General Psychology
  • Psychiatry and Mental health


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