SWNT-DNA and SWNT-polyC hybrids: AFM study and computer modeling

M. V. Karachevtsev, O. S. Lytvyn, S. G. Stepanian, V. S. Leontiev, L. Adamowicz, V. A. Karachevtsev

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Hybrids of carbon single-walled nanotubes (SWNT) with fragmented single or double-stranded DNA (fss- or fds-DNA) or polyC were studied by Atom Force Microscopy (AFM) and computer modeling. It was found that fragments of the polymer wrap in several layers around the nanotube, forming a strand-like spindle. In contrast to the fss-DNA, the fds-DNA also forms compact structures near the tube surface due to the formation of self-assembly structures consisting of a few DNA fragments. The hybrids of SWNT with wrapped single-, double- or triple strands of the biopolymer were simulated, and it was shown that such structures are stable. To explain the reason of multi-layer polymeric coating of the nanotube surface, the energy of the intermolecular interactions between different components of polyC was calculated at the MP2/6-31 ++G** level as well as the interaction energy in the SWNT-cytosine complex.

Original languageEnglish (US)
Pages (from-to)1473-1480
Number of pages8
JournalJournal of Nanoscience and Nanotechnology
Issue number3
StatePublished - Mar 2008


  • Ab initio calculation
  • Atom force microscopy
  • Biocompatibility
  • Bionanohybrids
  • Carbon nanotubes
  • DNA

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • Biomedical Engineering
  • General Materials Science
  • Condensed Matter Physics


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