Suspected ciliary dysfunction in Chinese Shar Pei pups with pneumonia.

C. R. Dhein, D. J. Prieur, M. W. Riggs, K. A. Potter, P. R. Widders

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Chronic pneumonia was investigated in a litter of young Chinese Shar Pei in which 4 of 6 dogs were affected. Serum immunoglobulin concentrations (IgA, IgG, IgM) determined by radial immunodiffusion varied over time, but were not consistently lower in affected dogs, compared with control dogs. Two dogs that died had hydrocephalus and lymphoid depletion, in addition to severe broncho-pneumonia. Evaluation of ciliary ultrastructure in 2 affected dogs revealed random orientation of adjacent respiratory tract or oviductal cilia and a greater number of microtubular disarrangements, compared with control dogs. In vivo tracheal mucociliary clearance of 99mtechnetium macroaggregated albumin was absent in 1 dog examined. The ciliary abnormalities were suspected to have resulted in an inefficient mucociliary transport system predisposing to the development of pneumonia. Further evaluation of 1 Chinese Shar Pei revealed lymphocyte mitogenesis results that were not consistently less than those of a control dog, normal total hemolytic complement values, and normal blood neutrophil chemotaxis.

Original languageEnglish (US)
Pages (from-to)439-446
Number of pages8
JournalAmerican journal of veterinary research
Issue number3
StatePublished - Mar 1990

ASJC Scopus subject areas

  • General Veterinary


Dive into the research topics of 'Suspected ciliary dysfunction in Chinese Shar Pei pups with pneumonia.'. Together they form a unique fingerprint.

Cite this