Susceptibility dynamics in neonatal BALB/c mice infected with Cryptosporidium parvum.

S. M. Novak, C. R. Sterling

    Research output: Contribution to journalArticlepeer-review

    29 Scopus citations

    Abstract

    BALB/c Mice were infected as neonates and at different ages to study the susceptibility dynamics in this animal model to Cryptosporidium parvum. When 4-day-old animals were infected with 10(5) C. parvum oocysts, parasites were detected in the terminal ileum when the mice became 14-25 days old (10-21 days post-infection [PI]). The percentage of animals positive for parasites was 100% up to the age of 19 days (15 days PI) but decreased immediately thereafter until no parasites were detected in 26-day-old (22 days PI) or older mice. Parasite load also decreased in these animals from 184.7 parasites per high power field in 14-day-old animals (10 days PI) to 0.22 in 25-day-old (21 days PI) mice. In a second study, some neonatal mice became resistant to C. parvum when infection was attempted at day-10 of age (day-15 of age at sacrifice). The susceptibility to C. parvum decreased until 14 days of age (19 days of age at sacrifice) when mice could no longer be infected. Parasite load also decreased in infected mice from 235.6 parasites per high power field (9 days of age at sacrifice) to 0.25 (18 days of age at sacrifice).

    Original languageEnglish (US)
    Pages (from-to)103S-104S
    JournalThe Journal of protozoology
    Volume38
    Issue number6
    StatePublished - 1991

    ASJC Scopus subject areas

    • Parasitology

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