TY - JOUR
T1 - Survival of cystic fibrosis patients undergoing liver and liver-lung transplantations
AU - Desai, C. S.
AU - Gruessner, A.
AU - Habib, S.
AU - Gruessner, R.
AU - Khan, K. M.
PY - 2013/1
Y1 - 2013/1
N2 - Background: We evaluated the outcome of combined liver-lung transplantation (L-LTx) in cystic fibrosis (CF) patients with liver transplantation (LTx) for CF liver disease. Methods: The United Network for Organ Sharing (UNOS) data were analyzed from October 1987 to August 2009. Results: Of 294 patients (210 children), 265 (90.1%) received an LTx and 29, an L-LTx. Patient survival was: adult LTx, 80%, 74%, and 67% at 1, 3, and 5 years, and L-LTx, 72%, 61.4%, and 61.4% (P =.7); pediatric LTx, 85%, 82%, and 74% at 1, 3, and 5 years, and L-LTx, 83%, 83%, and 83% (P =.4). Pediatric patients had a slight survival advantage over adults for LTx (P =.08). Graft survival, not affected by immunosuppression regimens, was similar to patient survival. Conclusions: The outcome of L-LTx appears similar to LTx in CF providing support for the prospect of a combined transplant.
AB - Background: We evaluated the outcome of combined liver-lung transplantation (L-LTx) in cystic fibrosis (CF) patients with liver transplantation (LTx) for CF liver disease. Methods: The United Network for Organ Sharing (UNOS) data were analyzed from October 1987 to August 2009. Results: Of 294 patients (210 children), 265 (90.1%) received an LTx and 29, an L-LTx. Patient survival was: adult LTx, 80%, 74%, and 67% at 1, 3, and 5 years, and L-LTx, 72%, 61.4%, and 61.4% (P =.7); pediatric LTx, 85%, 82%, and 74% at 1, 3, and 5 years, and L-LTx, 83%, 83%, and 83% (P =.4). Pediatric patients had a slight survival advantage over adults for LTx (P =.08). Graft survival, not affected by immunosuppression regimens, was similar to patient survival. Conclusions: The outcome of L-LTx appears similar to LTx in CF providing support for the prospect of a combined transplant.
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U2 - 10.1016/j.transproceed.2012.02.033
DO - 10.1016/j.transproceed.2012.02.033
M3 - Article
C2 - 23267790
AN - SCOPUS:84873314147
VL - 45
SP - 290
EP - 292
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 1
ER -