Survival after intravenous thrombin prior to cardiopulmonary bypass

Vance G. Nielsen, Samata R. Paidy, Camron A. Meek, Tiffany K. Thornton, Scott D. Lick

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We present a case of a patient undergoing aortic valve replacement being inadvertently administered 5000 U of bovine thrombin instead of heparin for anticoagulation for cardiopulmonary bypass. The labeling error was made within the operating room pharmacy. The key to survival of this patient was a rapid diagnosis, administration of antithrombin and heparin, and removal of cardiac and great vessel thrombi. It is recommended that point of care anesthesia providers `prepare heparin for cardiopulmonary bypass anticoagulation, as thrombin is not used in anesthetic practice and is not contained within anesthesia cabinet medication drawers.

Original languageEnglish (US)
Pages (from-to)485-487
Number of pages3
JournalInternational Journal of Legal Medicine
Issue number2
StatePublished - Mar 1 2017


  • Antithrombin
  • Cardiopulmonary bypass
  • Heparin
  • Medication error
  • Thrombin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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