TY - JOUR
T1 - Surgical treatment for heart failure
T2 - cell-based therapy with engineered tissue
AU - Lancaster, Jordan J.
AU - Koevary, Jen Watson
AU - Chinyere, Ikeotunye Royal
AU - Daugherty, Sherry L.
AU - Fox, Kenneth A.
AU - Goldman, Steven
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019
Y1 - 2019
N2 - This review will outline cell-based therapy for heart failure focusing on tissue engineering to deliver cells to the damaged heart. We will present an overview of the central approaches focusing on pluripotent stem cell-derived cells, mechanisms of action, autologous vs. allogeneic cell approaches, immunologic modulation, and safety considerations. We will outline the progress that has been made to-date and define the areas that still need to be investigated in order to advance the field.
AB - This review will outline cell-based therapy for heart failure focusing on tissue engineering to deliver cells to the damaged heart. We will present an overview of the central approaches focusing on pluripotent stem cell-derived cells, mechanisms of action, autologous vs. allogeneic cell approaches, immunologic modulation, and safety considerations. We will outline the progress that has been made to-date and define the areas that still need to be investigated in order to advance the field.
KW - Heart failure
KW - Induced pluripotent stem cells
KW - Tissue engineering
UR - https://www.scopus.com/pages/publications/85118574255
UR - https://www.scopus.com/inward/citedby.url?scp=85118574255&partnerID=8YFLogxK
U2 - 10.20517/2574-1209.2019.16
DO - 10.20517/2574-1209.2019.16
M3 - Review article
AN - SCOPUS:85118574255
SN - 2574-1209
VL - 3
JO - Vessel Plus
JF - Vessel Plus
M1 - 34
ER -