Surgical treatment for heart failure: cell-based therapy with engineered tissue

Jordan J. Lancaster, Jen Watson Koevary, Ikeotunye Royal Chinyere, Sherry L. Daugherty, Kenneth A. Fox, Steven Goldman

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


This review will outline cell-based therapy for heart failure focusing on tissue engineering to deliver cells to the damaged heart. We will present an overview of the central approaches focusing on pluripotent stem cell-derived cells, mechanisms of action, autologous vs. allogeneic cell approaches, immunologic modulation, and safety considerations. We will outline the progress that has been made to-date and define the areas that still need to be investigated in order to advance the field.

Original languageEnglish (US)
Article number34
JournalVessel Plus
StatePublished - 2019


  • Heart failure
  • Induced pluripotent stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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