Surgical techniques for total pancreatectomy and islet autotransplantation

Kaylene Barrera, Sidharth Sharma, Alexander Schwartzman, Rainer W.G. Gruessner

Research output: Chapter in Book/Report/Conference proceedingChapter


Since the first successful total pancreatectomy with islet autotransplant (TPIAT) for the treatment of chronic pancreatitis some 40 years ago, the procedure has finally gained more widespread acceptance as the only reliable and effective treatment option to preserve endocrine pancreatic function and improve or cure the associated chronic pain syndrome. TPIAT is a complex procedure with a wide range of potential complications that are intrinsic to its two components: total pancreatectomy (TP) and islet autotransplantation (IAT). Mounting evidence in the literature supports TPIAT as an approach that can be done safely at centers with experience using open, laparoscopic, and/or robotic techniques with little or no morbidity and mortality. From the surgical perspective, the procedure is standardized and can be safely performed in adult and pediatric patients with chronic pancreatitis.

Original languageEnglish (US)
Title of host publicationTransplantation, Bioengineering, and Regeneration of the Endocrine Pancreas
Subtitle of host publicationVolume 2
Number of pages16
ISBN (Electronic)9780128148310
ISBN (Print)9780128148327
StatePublished - Jan 1 2019
Externally publishedYes


  • Chronic pancreatitis
  • Completion pancreatectomy
  • Islet autotransplant
  • Robotic pancreatectomy
  • Total pancreatectomy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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