TY - JOUR
T1 - Surface-displayed glycopolymers of Clostridioides difficile
AU - Anwar, Farhan
AU - Vedantam, Gayatri
N1 - Funding Information:
This work was supported by funding from the National Institutes of Health [ R33AI121590531(GV) and the US Dept. of Veterans Affairs [ Research Career Scientist Award IK6BX003789(GV) ; and VA Merit Award I01BX001183(GV) ].
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/4
Y1 - 2022/4
N2 - Clostridioides difficile is a leading cause of the healthcare-associated disease C. difficile infection (CDI), which has an annual US burden of over 200 000 cases. CDI mitigation strategies have been complicated by the emergence, and widespread distribution, of phylogenetically diverse lineages, as well as pathogen recalcitrance to genetic manipulation. In this review, we highlight past and current efforts to elucidate C. difficile surface glycopolymer biology since these molecules are essential for colonization, disease, and immunity elicitation, and may therefore have potential as CDI anti-infective targets.
AB - Clostridioides difficile is a leading cause of the healthcare-associated disease C. difficile infection (CDI), which has an annual US burden of over 200 000 cases. CDI mitigation strategies have been complicated by the emergence, and widespread distribution, of phylogenetically diverse lineages, as well as pathogen recalcitrance to genetic manipulation. In this review, we highlight past and current efforts to elucidate C. difficile surface glycopolymer biology since these molecules are essential for colonization, disease, and immunity elicitation, and may therefore have potential as CDI anti-infective targets.
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U2 - 10.1016/j.mib.2022.01.007
DO - 10.1016/j.mib.2022.01.007
M3 - Review article
C2 - 35124522
AN - SCOPUS:85123900274
SN - 1369-5274
VL - 66
SP - 86
EP - 91
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -