Surface-displayed glycopolymers of Clostridioides difficile

Farhan Anwar, Gayatri Vedantam

Research output: Contribution to journalReview articlepeer-review

Abstract

Clostridioides difficile is a leading cause of the healthcare-associated disease C. difficile infection (CDI), which has an annual US burden of over 200 000 cases. CDI mitigation strategies have been complicated by the emergence, and widespread distribution, of phylogenetically diverse lineages, as well as pathogen recalcitrance to genetic manipulation. In this review, we highlight past and current efforts to elucidate C. difficile surface glycopolymer biology since these molecules are essential for colonization, disease, and immunity elicitation, and may therefore have potential as CDI anti-infective targets.

Original languageEnglish (US)
Pages (from-to)86-91
Number of pages6
JournalCurrent Opinion in Microbiology
Volume66
DOIs
StatePublished - Apr 2022

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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