Surface activation of blood coagulation, fibrinolysis and kinin formation

Ronald L. Heimark; Kotoku Kurachi; Kazuo Fujikawa; Earl W. Davie

doi:10.1038/286456a0

Surface activation of blood coagulation, fibrinolysis and kinin formation

Ronald L. Heimark
, Kotoku Kurachi
, Kazuo Fujikawa
, Earl W. Davie

Research output: Contribution to journal › Article › peer-review

127 Scopus citations

Abstract

The activation of plasma prekallikrein by single-chain factor XII has been studied in the presence of high molecular weight kininogen and kaolin. The data indicate that factor XII can initiate blood coagulation, fibrinolysis or kinin generation in the presence of kaolin and does so by converting prekallikrein to kallikrein. An enzyme cascade is then generated leading to the formation of fibrin, plasmin or bradykinin in three closely related physiological events.

Original language	English (US)
Pages (from-to)	456-460
Number of pages	5
Journal	Nature
Volume	286
Issue number	5772
DOIs	https://doi.org/10.1038/286456a0
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1038/286456a0

Cite this

@article{524ac3e9a6cf41e58a74915cd7700239,

title = "Surface activation of blood coagulation, fibrinolysis and kinin formation",

abstract = "The activation of plasma prekallikrein by single-chain factor XII has been studied in the presence of high molecular weight kininogen and kaolin. The data indicate that factor XII can initiate blood coagulation, fibrinolysis or kinin generation in the presence of kaolin and does so by converting prekallikrein to kallikrein. An enzyme cascade is then generated leading to the formation of fibrin, plasmin or bradykinin in three closely related physiological events.",

author = "Heimark, \{Ronald L.\} and Kotoku Kurachi and Kazuo Fujikawa and Davie, \{Earl W.\}",

year = "1980",

doi = "10.1038/286456a0",

language = "English (US)",

volume = "286",

pages = "456--460",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "5772",

}

TY - JOUR

T1 - Surface activation of blood coagulation, fibrinolysis and kinin formation

AU - Heimark, Ronald L.

AU - Kurachi, Kotoku

AU - Fujikawa, Kazuo

AU - Davie, Earl W.

PY - 1980

Y1 - 1980

N2 - The activation of plasma prekallikrein by single-chain factor XII has been studied in the presence of high molecular weight kininogen and kaolin. The data indicate that factor XII can initiate blood coagulation, fibrinolysis or kinin generation in the presence of kaolin and does so by converting prekallikrein to kallikrein. An enzyme cascade is then generated leading to the formation of fibrin, plasmin or bradykinin in three closely related physiological events.

AB - The activation of plasma prekallikrein by single-chain factor XII has been studied in the presence of high molecular weight kininogen and kaolin. The data indicate that factor XII can initiate blood coagulation, fibrinolysis or kinin generation in the presence of kaolin and does so by converting prekallikrein to kallikrein. An enzyme cascade is then generated leading to the formation of fibrin, plasmin or bradykinin in three closely related physiological events.

UR - https://www.scopus.com/pages/publications/0019314538

UR - https://www.scopus.com/pages/publications/0019314538#tab=citedBy

U2 - 10.1038/286456a0

DO - 10.1038/286456a0

M3 - Article

C2 - 6447254

AN - SCOPUS:0019314538

SN - 0028-0836

VL - 286

SP - 456

EP - 460

JO - Nature

JF - Nature

IS - 5772

ER -

Surface activation of blood coagulation, fibrinolysis and kinin formation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this