Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid

Jennifer Parker, Francisco Atez, Ronald G. Rossetti, Ann Skulas, Rakesh Patel, Robert B. Zurier

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Interleukin-6 (IL-6) is a multifunctional cytokine which contributes to inflammation and tissue injury in several diseases. Thus, inhibition of IL-6 production may be a useful strategy for treatment of patients with diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A synthetic nonpsychoactive cannabinoid, ajulemic acid (AjA), prevents joint damage in experimental arthritis. Results of experiments presented here indicate that addition of AjA (3-30 μM) to human monocyte derived macrophages in vitro reduces steady state levels of IL-6 mRNA and the subsequent secretion of IL-6 from LPS stimulated cells. Although AjA binds to and activates PPARγ, its anti IL-6 effects are PPARγ independent. These studies provide evidence to support the view that AjA may prove to be an effective, safe antiinflammatory agent.

Original languageEnglish (US)
Pages (from-to)631-635
Number of pages5
JournalRheumatology International
Volume28
Issue number7
DOIs
StatePublished - May 2008
Externally publishedYes

Keywords

  • Cannabinoid acid
  • Inflammation
  • Interleukin-6
  • Macrophages
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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