Suppression of hippocampal synaptic plasticity during slow-wave sleep

B. Jones Leonard; B. L. McNaughton; C. A. Barnes

doi:10.1016/0006-8993(87)90496-3

Suppression of hippocampal synaptic plasticity during slow-wave sleep

B. Jones Leonard
, B. L. McNaughton
, C. A. Barnes

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

The influence of behavioral state on the induction of long-term enhancement (LTE) of hippocampal synapses was studied in chronically prepared animals. Perforant path evoked field potentials and EEG were recorded from fascia dentata during slow-wave sleep (SWS) and waking. LTE was strongly suppressed during SWS, suggesting that hippocampal information storage may be inactivated at certain phases of the sleep cycle. Normal LTE was observed in the same animals while awake.

Original language	English (US)
Pages (from-to)	174-177
Number of pages	4
Journal	Brain Research
Volume	425
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(87)90496-3
State	Published - Nov 3 1987
Externally published	Yes

Keywords

(LTP)
Behavioral state
Field potential
Hippocampus
Learning
Long-term potentiation
Long-term synaptic enhancement
Memory
Sleep

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(87)90496-3

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title = "Suppression of hippocampal synaptic plasticity during slow-wave sleep",

abstract = "The influence of behavioral state on the induction of long-term enhancement (LTE) of hippocampal synapses was studied in chronically prepared animals. Perforant path evoked field potentials and EEG were recorded from fascia dentata during slow-wave sleep (SWS) and waking. LTE was strongly suppressed during SWS, suggesting that hippocampal information storage may be inactivated at certain phases of the sleep cycle. Normal LTE was observed in the same animals while awake.",

keywords = "(LTP), Behavioral state, Field potential, Hippocampus, Learning, Long-term potentiation, Long-term synaptic enhancement, Memory, Sleep",

author = "\{Jones Leonard\}, B. and McNaughton, \{B. L.\} and Barnes, \{C. A.\}",

note = "Funding Information: This research was supported by NIA Grant 03376,",

year = "1987",

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doi = "10.1016/0006-8993(87)90496-3",

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T1 - Suppression of hippocampal synaptic plasticity during slow-wave sleep

AU - Jones Leonard, B.

AU - McNaughton, B. L.

AU - Barnes, C. A.

N1 - Funding Information: This research was supported by NIA Grant 03376,

PY - 1987/11/3

Y1 - 1987/11/3

N2 - The influence of behavioral state on the induction of long-term enhancement (LTE) of hippocampal synapses was studied in chronically prepared animals. Perforant path evoked field potentials and EEG were recorded from fascia dentata during slow-wave sleep (SWS) and waking. LTE was strongly suppressed during SWS, suggesting that hippocampal information storage may be inactivated at certain phases of the sleep cycle. Normal LTE was observed in the same animals while awake.

AB - The influence of behavioral state on the induction of long-term enhancement (LTE) of hippocampal synapses was studied in chronically prepared animals. Perforant path evoked field potentials and EEG were recorded from fascia dentata during slow-wave sleep (SWS) and waking. LTE was strongly suppressed during SWS, suggesting that hippocampal information storage may be inactivated at certain phases of the sleep cycle. Normal LTE was observed in the same animals while awake.

KW - (LTP)

KW - Behavioral state

KW - Field potential

KW - Hippocampus

KW - Learning

KW - Long-term potentiation

KW - Long-term synaptic enhancement

KW - Memory

KW - Sleep

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DO - 10.1016/0006-8993(87)90496-3

M3 - Article

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AN - SCOPUS:0023275224

SN - 0006-8993

VL - 425

SP - 174

EP - 177

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Suppression of hippocampal synaptic plasticity during slow-wave sleep

Abstract

Keywords

ASJC Scopus subject areas

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