Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension

Bin Liu, Dan Yi, Jiakai Pan, Jingbo Dai, Maggie M. Zhu, You Yang Zhao, S. Paul Oh, Michael B. Fallon, Zhiyu Dai

Research output: Contribution to journalArticlepeer-review

Abstract

BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.

Original languageEnglish (US)
Article numbere12056
JournalPulmonary Circulation
Volume12
Issue number1
DOIs
StatePublished - Jan 2022

Keywords

  • BMPR2
  • angiogenesis
  • hypoxia
  • pulmonary hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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