@article{9a4b08bd50dc4e9683fd55bde82556b0,
title = "Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension",
abstract = "BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.",
keywords = "BMPR2, angiogenesis, hypoxia, pulmonary hypertension",
author = "Bin Liu and Dan Yi and Jiakai Pan and Jingbo Dai and Zhu, {Maggie M.} and Zhao, {You Yang} and Oh, {S. Paul} and Fallon, {Michael B.} and Zhiyu Dai",
note = "Funding Information: This study was supported in part by NIH grants R01HL140409, R01HL133951, R01HL148810 to You‐Yang Zhao, and NIH R00HL13827, AHA Career Development Award 20CDA35310084, ATS Foundation Pulmonary Hypertension Association Research Fellowship, Arizona Biomedical Research Centre funding (ADHS18‐198871), and the University of Arizona departmental Startup funding to Zhiyu Dai. The authors thank the Pulmonary Hypertension Breakthrough Initiative for providing the lung endothelial cells from IPAH patients and failed donors. Funding for the Pulmonary Hypertension Breakthrough Initiative is provided under an NHLBI R24 grant (R24HL123767). Publisher Copyright: {\textcopyright} 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.",
year = "2022",
month = jan,
doi = "10.1002/pul2.12056",
language = "English (US)",
volume = "12",
journal = "Pulmonary Circulation",
issn = "2045-8932",
publisher = "University of Chicago Press",
number = "1",
}