TY - JOUR
T1 - Suppression of Atrial Ectopy with Intravenous Metoprolol in Chronic Obstructive Pulmonary Disease Patients
AU - QUAN, STUART F.
AU - FENSTER, PAUL E.
AU - HANSON, CHRISTINE D.
AU - COAKER, LLOYD A.
AU - BASISTA, MICHAEL P.
PY - 1983
Y1 - 1983
N2 - Abstract: To determine the efficacy of a cardioselective beta blocker in the treatment of atrial ectopy in patients with chronic obstructive pulmonary disease (COPD), we administered intravenous metoprolol (0.2 mg/kg) to six patients with atrial ectopic depolarizations (AEDs) and chronic partially reversible airflow limitation (FEV1 = 1.24 ± 0.21 liter, mean ± S.E.). Metoprolol reduced the mean frequency of AEDs from 713 ± 237 per hour to 218 ± 127 per hour. Furthermore, three of six patients experienced an 85 per cent or greater decrease in AEDs. No changes were observed in FEV1, FVC, or FEF25–75 over the course of the study. These data suggest that intravenous metoprolol is effective in reducing the frequency of AEDs and that it can be administered to patients with COPD without causing an increase in airflow limitation. 1983 American College of Clinical Pharmacology
AB - Abstract: To determine the efficacy of a cardioselective beta blocker in the treatment of atrial ectopy in patients with chronic obstructive pulmonary disease (COPD), we administered intravenous metoprolol (0.2 mg/kg) to six patients with atrial ectopic depolarizations (AEDs) and chronic partially reversible airflow limitation (FEV1 = 1.24 ± 0.21 liter, mean ± S.E.). Metoprolol reduced the mean frequency of AEDs from 713 ± 237 per hour to 218 ± 127 per hour. Furthermore, three of six patients experienced an 85 per cent or greater decrease in AEDs. No changes were observed in FEV1, FVC, or FEF25–75 over the course of the study. These data suggest that intravenous metoprolol is effective in reducing the frequency of AEDs and that it can be administered to patients with COPD without causing an increase in airflow limitation. 1983 American College of Clinical Pharmacology
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U2 - 10.1002/j.1552-4604.1983.tb02746.x
DO - 10.1002/j.1552-4604.1983.tb02746.x
M3 - Article
C2 - 6630583
AN - SCOPUS:0020517448
SN - 0091-2700
VL - 23
SP - 341
EP - 347
JO - The Journal of Clinical Pharmacology
JF - The Journal of Clinical Pharmacology
IS - 8-9
ER -