@article{aa121c52ea184f2f86d8e3777437155a,
title = "Superantigen recognition by γδ T cells: SEA recognition site for human Vγ2 T cell receptors",
abstract = "Human γδ T cells expressing the Vγ2Vδ2 antigen receptors recognize nonpeptide prenyl pyrophosphate and alkylamine antigens. We find that they also recognize staphylococcal enterotoxin A superantigens in a manner distinct from the recognition of nonpeptide antigens. Using chimeric and mutant toxins, SEA amino acid residues 20-27 were shown to be required for γδ TCR recognition of SEA. Residues at 200-207 that are critical for specific αβ TCR recognition of SEA do not affect γδ TCR recognition. SEA residues 20-27 are located in an area contiguous with the binding site of V β chains. This study defines a superantigen recognition site for a γδ T cell receptor and demonstrates the differences between Vγ2Vδ2+ T cell recognition of superantigens and nonpeptide antigens.",
author = "Morita, {Craig T.} and Hongmin Li and Lamphear, {James G.} and Rich, {Robert R.} and Fraser, {John D.} and Mariuzza, {Roy A.} and Lee, {Hoi K.}",
note = "Funding Information: We thank Drs. K. D. Bieganowska and D. A. Hafler for the use of the Hy and Mo αβ T cell clones. We thank Drs. Jack Bukowski, Kia-Joo Puan, and Ki-Hoan Nam for critical reading of this manuscript. This work was supported by grants from the National Institutes of Health (C. T. M., R. R. R., and R. A. M.), American College of Rheumatology and Arthritis Foundation (C. T. M.), National Multiple Sclerosis Society (R. A. M.), the Richard Lounsbery Foundation (R.A.M.), Health Research Council of New Zealand (J. D. F.), the Auckland Medical Research Foundation (J.D.F.), and the International Frontiers for Science Program (J. D. F.). J. D. F. is a senior research fellow of the Welcome Trust (UK). H. K. L. received support from the American College of Rheumatology Research and Education Fund and the University of Iowa College of Medicine. ",
year = "2001",
doi = "10.1016/S1074-7613(01)00113-3",
language = "English (US)",
volume = "14",
pages = "331--344",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "3",
}