Abstract
Previous studies have showed that 99mTc labelled glucarate (GLA) might be an agent for non-invasive detection of breast tumours. In xenografted BT20 breast tumours, GLA was found to have higher uptake than 99mTc sestamibi (MIBI). It is unclear whether GLA can localize in all cell line breast cancer xenografts, as well as breast tumours with multidrug resistance (MDR). The present study aimed to investigate the properties of GLA in detecting drug sensitive and drug resistant MCF7 breast cancer xenografts in mice by using dynamic single photon emission computed tomography (SPECT) imaging.
Original language | English (US) |
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Pages (from-to) | 711-720 |
Number of pages | 10 |
Journal | Nuclear Medicine Communications |
Volume | 25 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2004 |
Keywords
- Breast cancer
- High-resolution SPECT
- Multidrug resistant
- SCID mice
- Tc glucarate
- Tc sestamibi
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging