Abstract
The specific binding of [3H]pirenzepine ([3H]PZ) and [3H](-) quinuclidinyl benzilate ([3H](-)QNB) was investigated in homogenates of human stellate ganglia. [3H]PZ saturation isotherms yielded a Kd of 14 nM and Bmax of 16.7 fmol/mg protein, while [3H](-)QNB binding curves yielded a Kd of 59 pM and Bmax of 33.0 fmol/mg protein. This represents the greatest proportion of high affinity [3H]PZ labeling, relative to [3H](-)QNB, seen in any peripheral tissue examined thus far.
Original language | English (US) |
---|---|
Pages (from-to) | 179-182 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 290 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2 1984 |
Keywords
- ganglia
- human
- muscarinic
- pirenzepine
- quinuclidinyl benzilate
- receptors
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology