31P-Nmr as a probe for drug-nucleic acid interactions

Frederick C. Seaman; Laurence H. Hurley

doi:10.1080/10426509908546240

³¹P-Nmr as a probe for drug-nucleic acid interactions

Frederick C. Seaman, Laurence H. Hurley

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The structural impact of covalent and noncovalent interactions of drugs with DNA is an important component for understanding the biochemical and biological consequences of DNA damage. Work in this laboratory has focused on a number of potentially therapeutically important drugs that distort DNA by unwinding, bending DNA into the major or minor groove. These lead to enhanced recognition of DNA by proteins involved in transcription and replication. In this paper, we will present the structures of one of these complexes and show how ³¹P-NMR can be used to monitor these distortive effects.

Original language	English (US)
Pages (from-to)	297-300
Number of pages	4
Journal	Phosphorus, Sulfur and Silicon and Related Elements
Volume	144-146
DOIs	https://doi.org/10.1080/10426509908546240
State	Published - 1999

Keywords

Bizelesin
Drug-DNA
Ecteinascidin
P-NMR
Quinolone

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Inorganic Chemistry

Access to Document

10.1080/10426509908546240

Cite this

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title = "31P-Nmr as a probe for drug-nucleic acid interactions",

abstract = "The structural impact of covalent and noncovalent interactions of drugs with DNA is an important component for understanding the biochemical and biological consequences of DNA damage. Work in this laboratory has focused on a number of potentially therapeutically important drugs that distort DNA by unwinding, bending DNA into the major or minor groove. These lead to enhanced recognition of DNA by proteins involved in transcription and replication. In this paper, we will present the structures of one of these complexes and show how 31P-NMR can be used to monitor these distortive effects.",

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author = "Seaman, {Frederick C.} and Hurley, {Laurence H.}",

note = "Funding Information: Acknowledgments This research was supported by a grant from the National Institutes of Health (CA-49751). We are grateful to David M. Bishop for preparing, proofreading, and editing the manuscript.",

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AU - Hurley, Laurence H.

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AB - The structural impact of covalent and noncovalent interactions of drugs with DNA is an important component for understanding the biochemical and biological consequences of DNA damage. Work in this laboratory has focused on a number of potentially therapeutically important drugs that distort DNA by unwinding, bending DNA into the major or minor groove. These lead to enhanced recognition of DNA by proteins involved in transcription and replication. In this paper, we will present the structures of one of these complexes and show how 31P-NMR can be used to monitor these distortive effects.

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KW - Ecteinascidin

KW - P-NMR

KW - Quinolone

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