[125I]SNF 8702: A selective radioligand for CCKB receptors

Jirina Slaninova; Richard J. Knapp; Steven J. Weber; Thomas P. Davis; Su Nan Fang; Victor J. Hruby; Henry I. Yamamura

doi:10.1016/0196-9781(94)00168-5

[¹²⁵I]SNF 8702: A selective radioligand for CCK_B receptors

Jirina Slaninova, Richard J. Knapp, Steven J. Weber, Thomas P. Davis, Su Nan Fang, Victor J. Hruby, Henry I. Yamamura

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The CCK-8 analogue, SNF 8702, was radioiodinated. [¹²⁵I]SNF 8702 showed high-affinity specific binding for both guinea pig and mouse brain tissues, whereas no specific binding was seen for guinea pig pancreatic tissue. The properties of the site labeled by [¹²⁵I]SNF 8702 were characterized by binding inhibition studies for a series of CCK_A and CCK_B receptor ligands. The binding selectivity profile corresponded to that for the CCK_B receptor. The labeled compound is stable for more than 6 weeks during storage at -20°C.

Original language	English (US)
Pages (from-to)	221-224
Number of pages	4
Journal	Peptides
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/0196-9781(94)00168-5
State	Published - 1995

Keywords

CCK receptors
Cholecystokinin
Radioiodinated cholecystokinin analogue
SNF 8702

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

Access to Document

10.1016/0196-9781(94)00168-5

Cite this

@article{333feaea4fa74768a89b0d3323fc388a,

title = "[125I]SNF 8702: A selective radioligand for CCKB receptors",

abstract = "The CCK-8 analogue, SNF 8702, was radioiodinated. [125I]SNF 8702 showed high-affinity specific binding for both guinea pig and mouse brain tissues, whereas no specific binding was seen for guinea pig pancreatic tissue. The properties of the site labeled by [125I]SNF 8702 were characterized by binding inhibition studies for a series of CCKA and CCKB receptor ligands. The binding selectivity profile corresponded to that for the CCKB receptor. The labeled compound is stable for more than 6 weeks during storage at -20°C.",

keywords = "CCK receptors, Cholecystokinin, Radioiodinated cholecystokinin analogue, SNF 8702",

author = "Jirina Slaninova and Knapp, \{Richard J.\} and Weber, \{Steven J.\} and Davis, \{Thomas P.\} and Fang, \{Su Nan\} and Hruby, \{Victor J.\} and Yamamura, \{Henry I.\}",

note = "Funding Information: was supported by NIH",

year = "1995",

doi = "10.1016/0196-9781(94)00168-5",

language = "English (US)",

volume = "16",

pages = "221--224",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "2",

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T1 - [125I]SNF 8702

T2 - A selective radioligand for CCKB receptors

AU - Slaninova, Jirina

AU - Knapp, Richard J.

AU - Weber, Steven J.

AU - Davis, Thomas P.

AU - Fang, Su Nan

AU - Hruby, Victor J.

AU - Yamamura, Henry I.

N1 - Funding Information: was supported by NIH

PY - 1995

Y1 - 1995

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AB - The CCK-8 analogue, SNF 8702, was radioiodinated. [125I]SNF 8702 showed high-affinity specific binding for both guinea pig and mouse brain tissues, whereas no specific binding was seen for guinea pig pancreatic tissue. The properties of the site labeled by [125I]SNF 8702 were characterized by binding inhibition studies for a series of CCKA and CCKB receptor ligands. The binding selectivity profile corresponded to that for the CCKB receptor. The labeled compound is stable for more than 6 weeks during storage at -20°C.

KW - CCK receptors

KW - Cholecystokinin

KW - Radioiodinated cholecystokinin analogue

KW - SNF 8702

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