Abstract
The CCK-8 analogue, SNF 8702, was radioiodinated. [125I]SNF 8702 showed high-affinity specific binding for both guinea pig and mouse brain tissues, whereas no specific binding was seen for guinea pig pancreatic tissue. The properties of the site labeled by [125I]SNF 8702 were characterized by binding inhibition studies for a series of CCKA and CCKB receptor ligands. The binding selectivity profile corresponded to that for the CCKB receptor. The labeled compound is stable for more than 6 weeks during storage at -20°C.
Original language | English (US) |
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Pages (from-to) | 221-224 |
Number of pages | 4 |
Journal | Peptides |
Volume | 16 |
Issue number | 2 |
DOIs | |
State | Published - 1995 |
Keywords
- CCK receptors
- Cholecystokinin
- Radioiodinated cholecystokinin analogue
- SNF 8702
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Endocrinology
- Cellular and Molecular Neuroscience