Sunscreen-Based skin protection against solar insult: Molecular mechanisms and opportunities

Georg T Wondrak

doi:10.1007/978-3-642-38983-2_11

Sunscreen-Based skin protection against solar insult: Molecular mechanisms and opportunities

Georg T Wondrak

Research output: Chapter in Book/Report/Conference proceeding › Chapter

11 Scopus citations

Abstract

Solar ultraviolet (UV) photons are established environmental carcinogens. Sunscreens are important solar photoprotectants and cancer chemopreventive molecular agents. The importance of efficient skin UVB (290-320 nm) photoprotection that attenuates photomutagenic events originating from direct absorption of UVB photons by DNA bases is firmly established. Cumulative evidence for the involvement of chronic UVA exposure in the causation of solar skin damage including photocarcinogenesis and photoaging now dictates the necessity for additional broadspectrum skin photoprotection that includes the UVA spectral region of sunlight. Based on the emerging consensus that broad spectrum photoprotection is an effective key component of a sun-safe strategy to reduce cumulative lifetime exposure to UV light, much effort has been directed towards the identification, development, and optimization of topical photoprotectants that prevent and attenuate solar skin damage.

Original language	English (US)
Title of host publication	Fundamentals of Cancer Prevention, Third Edition
Publisher	Springer Berlin Heidelberg
Pages	301-320
Number of pages	20
ISBN (Electronic)	9783642389832
ISBN (Print)	9783642389825
DOIs	https://doi.org/10.1007/978-3-642-38983-2_11
State	Published - Jan 1 2014

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-642-38983-2_11

Cite this

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abstract = "Solar ultraviolet (UV) photons are established environmental carcinogens. Sunscreens are important solar photoprotectants and cancer chemopreventive molecular agents. The importance of efficient skin UVB (290-320 nm) photoprotection that attenuates photomutagenic events originating from direct absorption of UVB photons by DNA bases is firmly established. Cumulative evidence for the involvement of chronic UVA exposure in the causation of solar skin damage including photocarcinogenesis and photoaging now dictates the necessity for additional broadspectrum skin photoprotection that includes the UVA spectral region of sunlight. Based on the emerging consensus that broad spectrum photoprotection is an effective key component of a sun-safe strategy to reduce cumulative lifetime exposure to UV light, much effort has been directed towards the identification, development, and optimization of topical photoprotectants that prevent and attenuate solar skin damage.",

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Sunscreen-Based skin protection against solar insult: Molecular mechanisms and opportunities

Abstract

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