Sultam thiourea inhibition of West Nile virus

Eric Barklis; Amelia Still; Mohammad I. Sabri; Alec J. Hirsch; Janko Nikolich-Zugich; James Brien; Tenzin Choesang Dhenub; Isabel Scholz; Ayna Alfadhli

doi:10.1128/AAC.00007-07

Sultam thiourea inhibition of West Nile virus

Eric Barklis
, Amelia Still
, Mohammad I. Sabri
, Alec J. Hirsch
, Janko Nikolich-Zugich
, James Brien
, Tenzin Choesang Dhenub
, Isabel Scholz
, Ayna Alfadhli

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.

Original language	English (US)
Pages (from-to)	2642-2645
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00007-07
State	Published - Jul 2007
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.00007-07

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abstract = "We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50\% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.",

author = "Eric Barklis and Amelia Still and Sabri, \{Mohammad I.\} and Hirsch, \{Alec J.\} and Janko Nikolich-Zugich and James Brien and Dhenub, \{Tenzin Choesang\} and Isabel Scholz and Ayna Alfadhli",

year = "2007",

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T1 - Sultam thiourea inhibition of West Nile virus

AU - Barklis, Eric

AU - Still, Amelia

AU - Sabri, Mohammad I.

AU - Hirsch, Alec J.

AU - Nikolich-Zugich, Janko

AU - Brien, James

AU - Dhenub, Tenzin Choesang

AU - Scholz, Isabel

AU - Alfadhli, Ayna

PY - 2007/7

Y1 - 2007/7

N2 - We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.

AB - We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.

UR - https://www.scopus.com/pages/publications/34447271709

UR - https://www.scopus.com/pages/publications/34447271709#tab=citedBy

U2 - 10.1128/AAC.00007-07

DO - 10.1128/AAC.00007-07

M3 - Article

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AN - SCOPUS:34447271709

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EP - 2645

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 7

ER -

Sultam thiourea inhibition of West Nile virus

Abstract

ASJC Scopus subject areas

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