Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously

Edita Navratilova, Frank Porreca

Research output: Contribution to journalShort surveypeer-review

38 Scopus citations


How do neuropeptides participate in the classic neuroinflammatory sequelae of tissue injury that includes pain, immune cell infiltration, and swelling? In this issue of Neuron, Green et al. (2019) reveal that MrgprB2/MrgprX2 is a mast cell substance-P-specific receptor that critically links neural and immune systems and offers new approaches for neuroinflammatory therapeutics.

Original languageEnglish (US)
Pages (from-to)353-355
Number of pages3
Issue number3
StatePublished - Feb 6 2019


  • MrgprB2 receptor
  • NK1 receptor
  • mast cells
  • neuroinflammation
  • pain
  • substance P

ASJC Scopus subject areas

  • General Neuroscience


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