Substance K and substance P in the ventral tegmental area

Peter W. Kalivas; Ariel Y. Deutch; John E. Maggio; Patrick W. Mantyh; Robert H. Roth

doi:10.1016/0304-3940(85)90498-7

Substance K and substance P in the ventral tegmental area

Peter W. Kalivas, Ariel Y. Deutch, John E. Maggio, Patrick W. Mantyh, Robert H. Roth

Pharmacology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

A comparison was made between substance P (SP) and substance K (SK) in the ventral tegmental area (VTA) (A10 dopamine cell group) of the rat. Approximately equal densities of SP and SK-immunoreactive neuronal fibers were observed. However, while previous reports demonstrate negligible density of autoradiographically defined SP receptors in the VTA, we observed a high density of SK receptors. SK or SP was microinjected into the VTA, and changes in spontaneous motor activity were measured using a photo-cell apparatus. SK was found to be at least 10 times more potent than SP in producing an increase in motor activity. These data suggest that while both SK and SP are present in the VTA, SK may have a more significant physiological role in modulating dopamine neurons in the ventromedial mesencephalon.

Original language	English (US)
Pages (from-to)	241-246
Number of pages	6
Journal	Neuroscience Letters
Volume	57
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(85)90498-7
State	Published - Jun 24 1985

Keywords

autoradiography
dopamine
immunocytochemistry
motor activity
receptor
substance K
substance P
ventral tegmental area

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(85)90498-7

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title = "Substance K and substance P in the ventral tegmental area",

abstract = "A comparison was made between substance P (SP) and substance K (SK) in the ventral tegmental area (VTA) (A10 dopamine cell group) of the rat. Approximately equal densities of SP and SK-immunoreactive neuronal fibers were observed. However, while previous reports demonstrate negligible density of autoradiographically defined SP receptors in the VTA, we observed a high density of SK receptors. SK or SP was microinjected into the VTA, and changes in spontaneous motor activity were measured using a photo-cell apparatus. SK was found to be at least 10 times more potent than SP in producing an increase in motor activity. These data suggest that while both SK and SP are present in the VTA, SK may have a more significant physiological role in modulating dopamine neurons in the ventromedial mesencephalon.",

keywords = "autoradiography, dopamine, immunocytochemistry, motor activity, receptor, substance K, substance P, ventral tegmental area",

author = "Kalivas, {Peter W.} and Deutch, {Ariel Y.} and Maggio, {John E.} and Mantyh, {Patrick W.} and Roth, {Robert H.}",

note = "Funding Information: We are grateful to Jan Ho and Diana Armstrong for typing and editing this manuscript. The research was supported by: NIH Grants DA-03906, MH-40817, MH-09156 and MH-14092; the Scottish Rite Schizophrenia Research Program; a Smith, Kline and Beckman Award; the Muscular Dystrophy Association; and the State of Connecticut.",

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AU - Kalivas, Peter W.

AU - Deutch, Ariel Y.

AU - Maggio, John E.

AU - Mantyh, Patrick W.

AU - Roth, Robert H.

N1 - Funding Information: We are grateful to Jan Ho and Diana Armstrong for typing and editing this manuscript. The research was supported by: NIH Grants DA-03906, MH-40817, MH-09156 and MH-14092; the Scottish Rite Schizophrenia Research Program; a Smith, Kline and Beckman Award; the Muscular Dystrophy Association; and the State of Connecticut.

PY - 1985/6/24

Y1 - 1985/6/24

N2 - A comparison was made between substance P (SP) and substance K (SK) in the ventral tegmental area (VTA) (A10 dopamine cell group) of the rat. Approximately equal densities of SP and SK-immunoreactive neuronal fibers were observed. However, while previous reports demonstrate negligible density of autoradiographically defined SP receptors in the VTA, we observed a high density of SK receptors. SK or SP was microinjected into the VTA, and changes in spontaneous motor activity were measured using a photo-cell apparatus. SK was found to be at least 10 times more potent than SP in producing an increase in motor activity. These data suggest that while both SK and SP are present in the VTA, SK may have a more significant physiological role in modulating dopamine neurons in the ventromedial mesencephalon.

AB - A comparison was made between substance P (SP) and substance K (SK) in the ventral tegmental area (VTA) (A10 dopamine cell group) of the rat. Approximately equal densities of SP and SK-immunoreactive neuronal fibers were observed. However, while previous reports demonstrate negligible density of autoradiographically defined SP receptors in the VTA, we observed a high density of SK receptors. SK or SP was microinjected into the VTA, and changes in spontaneous motor activity were measured using a photo-cell apparatus. SK was found to be at least 10 times more potent than SP in producing an increase in motor activity. These data suggest that while both SK and SP are present in the VTA, SK may have a more significant physiological role in modulating dopamine neurons in the ventromedial mesencephalon.

KW - autoradiography

KW - dopamine

KW - immunocytochemistry

KW - motor activity

KW - receptor

KW - substance K

KW - substance P

KW - ventral tegmental area

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Substance K and substance P in the ventral tegmental area

Abstract

Keywords

ASJC Scopus subject areas

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