@article{0957481564e14909a1c4f9e63abb95e0,
title = "Subjective Sleep Quality and Trajectories of Interleukin-6 in Older Adults",
abstract = "Background: We aimed to identify trajectories of inflammation in older adults at elevated risk for syndromal depression and anxiety and to determine whether baseline physical, cognitive, and psychosocial factors could distinguish 15-month longitudinal trajectories. Methods: Older adults (N = 195, mean age (±SD) = 74.4 years (9.0) participating in three depression and anxiety prevention protocols completed a comprehensive battery of psychosocial assessments and provided blood samples for analysis of interleukin-6 (IL-6) every 3 months over a maximum of 15 months. Group-based trajectory modeling identified trajectories. Adjusted logistic regression examined associations between baseline factors and trajectory groups. Results: Two 15-month trajectories were identified: stable lower IL-6 levels (84%; mean (±SD) = 3.2 (2.1) pg/mL); and consistently higher IL-6 levels (16%; mean = 9.5 (7.4) pg/mL). Poor sleep quality predicted consistently higher levels of IL-6 (OR = 1.9, 95% CI = 1.03–3.55). Conclusion: Poor sleep quality may represent a therapeutic target to reduce inflammation.",
keywords = "Aging, circadian rhythms, cytokines, inflammation, sleep",
author = "Stahl, {Sarah T.} and Smagula, {Stephen F.} and Juleen Rodakowski and Dew, {Mary Amanda} and Karp, {Jordan F.} and Albert, {Steven M.} and Meryl Butters and Ariel Gildengers and Reynolds, {Charles F.}",
note = "Funding Information: Funding: Supported in part by P30 MH090333, CTSI UL1RR024153, UL1TR000005, MH118270 (Stahl), and AG056351 (Rodakowski, Butters) from the National Institutes of Health. Disclosures and Potential Conflicts of Interest: JFK has received medication supplies for investigator-initiated trials from Pfizer and Indivior. He receives honoraria from American Journal of Geriatric Psychiatry and Journal of Clinical Psychiatry. CFR has received research support from the NIH, the Patient Centered Outcomes Research Institute, the Center for Medicare and Medicaid Services, the American Foundation for Suicide Prevention, the Brain and Behavior Research Foundation, and the Commonwealth of Pennsylvania. Bristol Meyer Squib and Pfizer have provided pharmaceutical supplies for his NIH sponsored research. He is a paid consultant to Merck. The other authors have nothing to disclose. Funding Information: Disclosures and Potential Conflicts of Interest: JFK has received medication supplies for investigator-initiated trials from Pfizer and Indivior. He receives honoraria from American Journal of Geriatric Psychiatry and Journal of Clinical Psychiatry. CFR has received research support from the NIH, the Patient Centered Outcomes Research Institute, the Center for Medicare and Medicaid Services, the American Foundation for Suicide Prevention, the Brain and Behavior Research Foundation, and the Commonwealth of Pennsylvania. Bristol Meyer Squib and Pfizer have provided pharmaceutical supplies for his NIH sponsored research. He is a paid consultant to Merck. The other authors have nothing to disclose. Publisher Copyright: {\textcopyright} 2020 American Association for Geriatric Psychiatry",
year = "2021",
month = feb,
doi = "10.1016/j.jagp.2020.06.019",
language = "English (US)",
volume = "29",
pages = "204--208",
journal = "American Journal of Geriatric Psychiatry",
issn = "1064-7481",
publisher = "Lippincott Williams and Wilkins",
number = "2",
}