Studies on medicinal plants of sri lanka. part 14: toxicity of some traditional medicinal herbs

Sarath N. Arseculeratne; A. A.Leslie Gunatilaka; Ralph G. Panabokke

doi:10.1016/0378-8741(85)90078-9

Studies on medicinal plants of sri lanka. part 14: toxicity of some traditional medicinal herbs

Sarath N. Arseculeratne, A. A.Leslie Gunatilaka, Ralph G. Panabokke

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103 Scopus citations

Abstract

Seventy five medicinal plants of the traditional Ayurvedic pharmacopoeia of Sri Lanka have been screened chemically for alkaloids and pyrrolizidine alkaloids. Of these, Crotolaria juncea L. was found to contain pyrrolizidine alkaloids with biological effects consistent with pyrrolizidine alkaloid toxicity. Feeding trials in rats with three plants lacking pyrrolizidine alkaloids, namely Aegle marmelos (L.) Corr., Hemidesmus indicus (L.) Ait. F. and Terminalia chebula Retz. produced hepatic lesions which included central vein abnormalities while Terminalia chebula and Withania somnifera (L.) Dunal produced marked renal lesions.

Original language	English (US)
Pages (from-to)	323-335
Number of pages	13
Journal	Journal of Ethnopharmacology
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/0378-8741(85)90078-9
State	Published - Jul 1985
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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@article{e3c31bae49b84095a3a1d7d4a66424d4,

title = "Studies on medicinal plants of sri lanka. part 14: toxicity of some traditional medicinal herbs",

abstract = "Seventy five medicinal plants of the traditional Ayurvedic pharmacopoeia of Sri Lanka have been screened chemically for alkaloids and pyrrolizidine alkaloids. Of these, Crotolaria juncea L. was found to contain pyrrolizidine alkaloids with biological effects consistent with pyrrolizidine alkaloid toxicity. Feeding trials in rats with three plants lacking pyrrolizidine alkaloids, namely Aegle marmelos (L.) Corr., Hemidesmus indicus (L.) Ait. F. and Terminalia chebula Retz. produced hepatic lesions which included central vein abnormalities while Terminalia chebula and Withania somnifera (L.) Dunal produced marked renal lesions.",

author = "Arseculeratne, {Sarath N.} and Gunatilaka, {A. A.Leslie} and Panabokke, {Ralph G.}",

note = "Funding Information: We are thankful to Messrs. V.S.B. Imbuldeniya and Ayomal Fernando for technical assistance; Mrs. S.C. Weerasekera for typing the manuscript. This project was supported by grants from the Natural Resources, Energy and Science Authority of Sri Lanka, International Foundation for Science (Sweden) and the Swedish Agency for Research Cooperation with Developing Countries (SAREC).",

year = "1985",

month = jul,

doi = "10.1016/0378-8741(85)90078-9",

language = "English (US)",

volume = "13",

pages = "323--335",

journal = "Journal of Ethnopharmacology",

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number = "3",

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T1 - Studies on medicinal plants of sri lanka. part 14

T2 - toxicity of some traditional medicinal herbs

AU - Arseculeratne, Sarath N.

AU - Gunatilaka, A. A.Leslie

AU - Panabokke, Ralph G.

N1 - Funding Information: We are thankful to Messrs. V.S.B. Imbuldeniya and Ayomal Fernando for technical assistance; Mrs. S.C. Weerasekera for typing the manuscript. This project was supported by grants from the Natural Resources, Energy and Science Authority of Sri Lanka, International Foundation for Science (Sweden) and the Swedish Agency for Research Cooperation with Developing Countries (SAREC).

PY - 1985/7

Y1 - 1985/7

N2 - Seventy five medicinal plants of the traditional Ayurvedic pharmacopoeia of Sri Lanka have been screened chemically for alkaloids and pyrrolizidine alkaloids. Of these, Crotolaria juncea L. was found to contain pyrrolizidine alkaloids with biological effects consistent with pyrrolizidine alkaloid toxicity. Feeding trials in rats with three plants lacking pyrrolizidine alkaloids, namely Aegle marmelos (L.) Corr., Hemidesmus indicus (L.) Ait. F. and Terminalia chebula Retz. produced hepatic lesions which included central vein abnormalities while Terminalia chebula and Withania somnifera (L.) Dunal produced marked renal lesions.

AB - Seventy five medicinal plants of the traditional Ayurvedic pharmacopoeia of Sri Lanka have been screened chemically for alkaloids and pyrrolizidine alkaloids. Of these, Crotolaria juncea L. was found to contain pyrrolizidine alkaloids with biological effects consistent with pyrrolizidine alkaloid toxicity. Feeding trials in rats with three plants lacking pyrrolizidine alkaloids, namely Aegle marmelos (L.) Corr., Hemidesmus indicus (L.) Ait. F. and Terminalia chebula Retz. produced hepatic lesions which included central vein abnormalities while Terminalia chebula and Withania somnifera (L.) Dunal produced marked renal lesions.

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ER -

Studies on medicinal plants of sri lanka. part 14: toxicity of some traditional medicinal herbs

Abstract

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