Studies of the effects of spherulin from Coccidioides immitis on human polymorpho-nuclear leukocytes

John N. Galgiani

doi:10.1007/BF00436860

Studies of the effects of spherulin from Coccidioides immitis on human polymorpho-nuclear leukocytes

John N. Galgiani

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Abstract

The effects of spherule lysate (spherulin) on human polymorphonuclear leukocyte (PMN) function was examined. PMN adherence to glass and capping was increased by spherulin, findings which may account for spherulin's interference with complement-mediated migration through cellulose ester filters. In contrast, PMN attachment to yeast, killing of bacteria, and effects on spherules were virtually unaffected by spherulin, suggesting that it does not directly inhibit PMN antimicrobial function.

Original language	English (US)
Pages (from-to)	107-111
Number of pages	5
Journal	Mycopathologia
Volume	90
Issue number	2
DOIs	https://doi.org/10.1007/BF00436860
State	Published - May 1985

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology
Agronomy and Crop Science
veterinary (miscalleneous)

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abstract = "The effects of spherule lysate (spherulin) on human polymorphonuclear leukocyte (PMN) function was examined. PMN adherence to glass and capping was increased by spherulin, findings which may account for spherulin's interference with complement-mediated migration through cellulose ester filters. In contrast, PMN attachment to yeast, killing of bacteria, and effects on spherules were virtually unaffected by spherulin, suggesting that it does not directly inhibit PMN antimicrobial function.",

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AB - The effects of spherule lysate (spherulin) on human polymorphonuclear leukocyte (PMN) function was examined. PMN adherence to glass and capping was increased by spherulin, findings which may account for spherulin's interference with complement-mediated migration through cellulose ester filters. In contrast, PMN attachment to yeast, killing of bacteria, and effects on spherules were virtually unaffected by spherulin, suggesting that it does not directly inhibit PMN antimicrobial function.

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Studies of the effects of spherulin from Coccidioides immitis on human polymorpho-nuclear leukocytes

Abstract

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