TY - JOUR
T1 - Studies in vivo with dynorphin-(1-9)
T2 - Analgesia but not gastrointestinal effects following intrathecal administration to mice
AU - Porreca, Frank
AU - Filla, Alessandro
AU - Burks, Thomas F.
N1 - Funding Information:
This study was supported by Grant DA 02163 from the National Institute on Drug Abuse and FP was the recipient of a Merck Postdoctoral Fellowship.
PY - 1983/7/22
Y1 - 1983/7/22
N2 - Direct administration of dynorphin-(1-9) (10-100 μg) into the spinal subarachnoid space of mice produced a dose-related analgesic effect at 5 and 10, but not 35 min, in the tail-flick test using hot water as the nociceptive stimulus. By contrast, the same doses did not affect gastrointestinal transit at 5, 10, 15 or 35 min after injection. These results suggest that dynorphin-(1-9) is similar in this endpoint to ketazocine-type κ opioid agonists in naive animals while confirming that intrathecal administration of dynorphin is analgesic in mice.
AB - Direct administration of dynorphin-(1-9) (10-100 μg) into the spinal subarachnoid space of mice produced a dose-related analgesic effect at 5 and 10, but not 35 min, in the tail-flick test using hot water as the nociceptive stimulus. By contrast, the same doses did not affect gastrointestinal transit at 5, 10, 15 or 35 min after injection. These results suggest that dynorphin-(1-9) is similar in this endpoint to ketazocine-type κ opioid agonists in naive animals while confirming that intrathecal administration of dynorphin is analgesic in mice.
KW - Analgesia
KW - Dynorphin-(1-9)
KW - Gastrointestinal transit
KW - Intrathecal administration
KW - Mice
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U2 - 10.1016/0014-2999(83)90481-8
DO - 10.1016/0014-2999(83)90481-8
M3 - Article
C2 - 6137394
AN - SCOPUS:0020643094
VL - 91
SP - 291
EP - 294
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -