Studies in Phlebitis: Detection and Quantitation Using a Thermographic Camera

Gary H. Ward, Paul E. Nolan, Monica Chawla, Samuel H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A new method for the detection of acute phlebitis in superficial veins is investigated. A thermographic camera is utilized for the quantitation of temperature changes in a rabbit ear model. A control group receiving no injection is compared against each of five treatment groups receiving these commercially available parenterals: amiodarone hydrochloride, phenytoin sodium, mechlorethamine hydrochloride, cephalothin sodium, and diazepam. The vehicles of the above-mentioned drugs as well as several commonly used organic cosolvents are also investigated. Local tissue responses to the parenteral challenges are measured and a good correlation between the visual and the thermographic data was seen.

Original languageEnglish (US)
Pages (from-to)76-79
Number of pages4
JournalPharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Issue number1
StatePublished - Jan 1991


  • detection
  • inflammation
  • parenterals
  • phlebitis
  • thermography
  • thrombophlebitis

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)


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