Abstract
Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K+ solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5′-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.
Original language | English (US) |
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Article number | gkp1029 |
Pages (from-to) | 1009-1021 |
Number of pages | 13 |
Journal | Nucleic acids research |
Volume | 38 |
Issue number | 3 |
DOIs | |
State | Published - Nov 27 2009 |
ASJC Scopus subject areas
- Genetics
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Human telomere DNA two-tetrad quadruplex structure in K+ solution
Zhang, Z. (Contributor), Dai, J. (Contributor), Veliath, E. (Contributor), Jones, R. A. (Contributor) & Yang, D. (Contributor), Protein Data Bank (PDB), Dec 15 2009
DOI: 10.2210/pdb2KKA/pdb, https://www.wwpdb.org/pdb?id=pdb_00002kka
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