Abstract
Biotransformation of monocillin I (1) by Beauveria bassiana ATCC 7159 was investigated. Two new derivatives 2 and 3 were isolated and identified on the basis of the spectroscopic data. Compounds 2 and 3 are synthesized by hydration at 10,11-double bond and hydrolysis of 14,15-epoxide, respectively. The R configuration of 11-OH in 2 was established by the modified 2-methoxy-2- trifluoromethylphenylacetic acid (MTPA) method. The conversion of 1 to 2 and 3 was reconstituted in an acid solution, indicating that the formation of 2 and 3 is an acid-catalyzed instead of an enzymatic process.
Original language | English (US) |
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Pages (from-to) | 801-804 |
Number of pages | 4 |
Journal | Natural Product Communications |
Volume | 5 |
Issue number | 5 |
DOIs | |
State | Published - 2010 |
Keywords
- Beauveria bassiana
- Hydration
- Hydrolysis
- MTPA esters
- Monocillin I
ASJC Scopus subject areas
- Pharmacology
- Plant Science
- Drug Discovery
- Complementary and alternative medicine