Abstract
ERβ has been associated with estrogen-induced promotion of memory function and neuronal survival. Based on the optimized complex structure of human ERβ LBD bound with genistein, computer-aided structure-based virtual screening against a natural source chemical database was conducted to determine the occurrence of plant-based ERβ-selective ligands. Twelve representative hits derived from database screening were assessed for their binding profiles to both ERs, three of which displayed over 100-fold binding selectivity to ERβ over ERα.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3463-3466 |
| Number of pages | 4 |
| Journal | Journal of Medicinal Chemistry |
| Volume | 48 |
| Issue number | 10 |
| DOIs | |
| State | Published - May 19 2005 |
| Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
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