Abstract
DNA repair is fundamental to genome stability and is found in all three domains of life. However many archaeal species, such as Methanopyrus kandleri, contain only a subset of the eukaryotic nucleotide excision repair (NER) homologs, and those present often contain significant differences compared to their eukaryotic homologs. To clarify the role of the NER XPG-like protein Mk0566 from M. kandleri, its biochemical activity and three-dimensional structure were investigated. Both were found to be more similar to human FEN-1 than human XPG, suggesting a biological role in replication and long-patch base excision repair rather than in NER.
Original language | English (US) |
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Pages (from-to) | 188-194 |
Number of pages | 7 |
Journal | Proteins: Structure, Function and Bioinformatics |
Volume | 83 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2015 |
Keywords
- DNA nuclease
- Nucleotide excision repair
- Protein-DNA complex
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Molecular Biology