@article{67c4bd266db64eb6a0a014f2193d8931,
title = "Structure and function of a transcriptional network activated by the MAPK Hog1",
abstract = "Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. To gain insight into the structure and function of these networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast. Our model reveals that the Hog1 and general stress (Msn2/4) pathways interact, at both the signaling and promoter level, to integrate information and create a context-dependent response. This study lays out a path to identifying and characterizing the role of signal integration and processing in other gene regulatory networks.",
author = "Capaldi, {Andrew P.} and Tommy Kaplan and Ying Liu and Naomi Habib and Aviv Regev and Nir Friedman and O{\textquoteright}shea, {Erin K.}",
note = "Funding Information: We thank D. Steger, D. Wykoff, A. Carroll and C. Hopkins from Agilent for advice regarding microarray, ChIP and other procedures; T. Lee and R. Young for sharing their tiling-array design and hybridization protocol before publication; H. Margalit and members of the O{\textquoteright}Shea, Friedman and Regev laboratories for helpful discussions; and P. Grosu for help with Rosetta Resolver. We are also grateful to E. Lander, D. Pe{\textquoteright}er, D. Koller, R. Losick, M. Brenner and B. Stern for reading the manuscript before publication. A.P.C. was a Howard Hughes Medical Institute (HHMI) Fellow of the Life Sciences Research Foundation and A.R. was supported by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund. This work was supported by HHMI (E.K.O.) and a grant from the Human Frontiers Science Program (E.K.O., A.R. and N.F.).",
year = "2008",
month = nov,
doi = "10.1038/ng.235",
language = "English (US)",
volume = "40",
pages = "1300--1306",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "11",
}