Structural characteristics of two highly selective opioid peptides

Richard J. Knapp; Henry I. Yamamura; Wieslaw Kazmierski; Victor J. Hruby

doi:10.1002/bies.950100206

Structural characteristics of two highly selective opioid peptides

Richard J. Knapp, Henry I. Yamamura, Wieslaw Kazmierski, Victor J. Hruby

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The demonstration of opioid receptors by radioligand binding and the discovery of their endogenous peptide ligands has provided a new class of compounds that can be used for the development of novel opioids. The number of potential receptor targets for such opioids has been expanded by the identification of multiple opioid receptor types The development of highly selective opioid peptides using the principles of conformational restriction permits the analysis of the structure‐activity requirements of each receptor type, and is facilitating the elucidation of the functional properties of the different opioid receptors.

Original language	English (US)
Pages (from-to)	58-61
Number of pages	4
Journal	BioEssays
Volume	10
Issue number	2-3
DOIs	https://doi.org/10.1002/bies.950100206
State	Published - Feb 1989
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1002/bies.950100206

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author = "Knapp, {Richard J.} and Yamamura, {Henry I.} and Wieslaw Kazmierski and Hruby, {Victor J.}",

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AU - Kazmierski, Wieslaw

AU - Hruby, Victor J.

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AB - The demonstration of opioid receptors by radioligand binding and the discovery of their endogenous peptide ligands has provided a new class of compounds that can be used for the development of novel opioids. The number of potential receptor targets for such opioids has been expanded by the identification of multiple opioid receptor types The development of highly selective opioid peptides using the principles of conformational restriction permits the analysis of the structure‐activity requirements of each receptor type, and is facilitating the elucidation of the functional properties of the different opioid receptors.

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Structural characteristics of two highly selective opioid peptides

Abstract

ASJC Scopus subject areas

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