Stroke: Development, prevention and treatment with peptidase inhibitors

K. S. Mark, T. P. Davis

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Stroke is the leading cause of long-term disability in the United States and affects more people than any other neurologic disorder. Hypertension is a major risk factor associated with stroke. Several anti-hypertensive agents have been used to treat chronic hypertension to reduce the morbidity and mortality of stroke. Previous experimental studies have shown reduced stroke mortality with angiotensin-converting enzyme (ACE) inhibitors. This review discusses the development of stroke and potential use of ACE inhibitors in prevention and treatment of this disease. Furthermore, this review focuses on current investigations aimed at cellular mechanisms involved in stroke-induced microvascular alterations.

Original languageEnglish (US)
Pages (from-to)1965-1973
Number of pages9
Issue number12
StatePublished - Dec 2000


  • ACE inhibitors
  • Cellular mechanisms
  • Hypertension
  • Hypoxia/reoxygenation
  • Stroke

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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