Stress granules and ALS: A case of causation or correlation?

Nikita Fernandes, Nichole Eshleman, John R Buchan

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Scopus citations


Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. These aggregates are linked to ALS pathogenesis. Recent evidence has suggested that stress granules may aid the formation of ALS protein aggregates. Here, we summarize current understanding of stress granules, focusing on assembly and clearance. We also assess the evidence linking alterations in stress granule formation and dynamics to ALS protein aggregates and disease pathology.

Original languageEnglish (US)
Title of host publicationAdvances in Neurobiology
PublisherSpringer New York LLC
Number of pages40
StatePublished - 2018

Publication series

NameAdvances in Neurobiology
ISSN (Print)2190-5215


  • ALS
  • Autophagy
  • C9ORF72
  • Chaperones
  • Cytoskeleton
  • FUS
  • SOD1
  • Stress granules
  • TDP-43
  • mRNA

ASJC Scopus subject areas

  • Biochemistry
  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience


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