Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

Jessica J. Walsh; Allyson K. Friedman; Haosheng Sun; Elizabeth A. Heller; Stacy M. Ku; Barbara Juarez; Veronica L. Burnham; Michelle S. Mazei-Robison; Deveroux Ferguson; Sam A. Golden; Ja Wook Koo; Dipesh Chaudhury; Daniel J. Christoffel; Lisa Pomeranz; Jeffrey M. Friedman; Scott J. Russo; Eric J. Nestler; Ming Hu Han

doi:10.1038/nn.3591

Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

Jessica J. Walsh
, Allyson K. Friedman
, Haosheng Sun
, Elizabeth A. Heller
, Stacy M. Ku
, Barbara Juarez
, Veronica L. Burnham
, Michelle S. Mazei-Robison
, Deveroux Ferguson
, Sam A. Golden
, Ja Wook Koo
, Dipesh Chaudhury
, Daniel J. Christoffel
, Lisa Pomeranz
, Jeffrey M. Friedman
, Scott J. Russo
, Eric J. Nestler
, Ming Hu Han

Research output: Contribution to journal › Article › peer-review

187 Scopus citations

Abstract

Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.

Original language	English (US)
Pages (from-to)	27-29
Number of pages	3
Journal	Nature neuroscience
Volume	17
Issue number	1
DOIs	https://doi.org/10.1038/nn.3591
State	Published - Jan 2014
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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Walsh, J. J., Friedman, A. K., Sun, H., Heller, E. A., Ku, S. M., Juarez, B., Burnham, V. L., Mazei-Robison, M. S., Ferguson, D., Golden, S. A., Koo, J. W., Chaudhury, D., Christoffel, D. J., Pomeranz, L., Friedman, J. M., Russo, S. J., Nestler, E. J., & Han, M. H. (2014). Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nature neuroscience, 17(1), 27-29. https://doi.org/10.1038/nn.3591

Walsh, JJ, Friedman, AK, Sun, H, Heller, EA, Ku, SM, Juarez, B, Burnham, VL, Mazei-Robison, MS, Ferguson, D, Golden, SA, Koo, JW, Chaudhury, D, Christoffel, DJ, Pomeranz, L, Friedman, JM, Russo, SJ, Nestler, EJ & Han, MH 2014, 'Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway', Nature neuroscience, vol. 17, no. 1, pp. 27-29. https://doi.org/10.1038/nn.3591

@article{be0d6da966914d92bf3cb6e348f3f027,

title = "Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway",

abstract = "Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.",

author = "Walsh, \{Jessica J.\} and Friedman, \{Allyson K.\} and Haosheng Sun and Heller, \{Elizabeth A.\} and Ku, \{Stacy M.\} and Barbara Juarez and Burnham, \{Veronica L.\} and Mazei-Robison, \{Michelle S.\} and Deveroux Ferguson and Golden, \{Sam A.\} and Koo, \{Ja Wook\} and Dipesh Chaudhury and Christoffel, \{Daniel J.\} and Lisa Pomeranz and Friedman, \{Jeffrey M.\} and Russo, \{Scott J.\} and Nestler, \{Eric J.\} and Han, \{Ming Hu\}",

note = "Funding Information: This work was supported by the National Institute of Mental Health (R01 MH092306: D.C. and M.-H.H.), Johnson \& Johnson/International Mental Health Research Organization Rising Star Translational Research Award (M.-H.H.) and National Research Service Awards (F31 MH095425: J.J.W.; F32 MH096464: A.K.F.).",

year = "2014",

month = jan,

doi = "10.1038/nn.3591",

language = "English (US)",

volume = "17",

pages = "27--29",

journal = "Nature neuroscience",

issn = "1097-6256",

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AU - Walsh, Jessica J.

AU - Friedman, Allyson K.

AU - Sun, Haosheng

AU - Heller, Elizabeth A.

AU - Ku, Stacy M.

AU - Juarez, Barbara

AU - Burnham, Veronica L.

AU - Mazei-Robison, Michelle S.

AU - Ferguson, Deveroux

AU - Golden, Sam A.

AU - Koo, Ja Wook

AU - Chaudhury, Dipesh

AU - Christoffel, Daniel J.

AU - Pomeranz, Lisa

AU - Friedman, Jeffrey M.

AU - Russo, Scott J.

AU - Nestler, Eric J.

AU - Han, Ming Hu

N1 - Funding Information: This work was supported by the National Institute of Mental Health (R01 MH092306: D.C. and M.-H.H.), Johnson & Johnson/International Mental Health Research Organization Rising Star Translational Research Award (M.-H.H.) and National Research Service Awards (F31 MH095425: J.J.W.; F32 MH096464: A.K.F.).

PY - 2014/1

Y1 - 2014/1

N2 - Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.

AB - Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.

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ER -

Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

Abstract

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