TY - JOUR
T1 - Strategies of obligate intracellular parasites for evading host defences
AU - Hall, B. Fenton
AU - Joiner, Keith A.
PY - 1991
Y1 - 1991
N2 - During the course of establishing infection in a susceptible host, obligate intracellular parasites evade host defence mechanisms before, during and after entry into host cells. Before entry they circumvent the lytic activity of the complement cascade, during cell entry they avoid being killed by toxic oxygen metabolites and after entry they escape nonoxidative killing mechanisms such as degradation by lysosomal hydrolases. Different intracellular parasites, exemplified here by Leishmania spp, Trypanosoma cruzi and Toxoplasma gondii, undermine host defences at each step by various strategies that ultimately ensure their targeting to, and survival in, an appropriate intracellular compartment.
AB - During the course of establishing infection in a susceptible host, obligate intracellular parasites evade host defence mechanisms before, during and after entry into host cells. Before entry they circumvent the lytic activity of the complement cascade, during cell entry they avoid being killed by toxic oxygen metabolites and after entry they escape nonoxidative killing mechanisms such as degradation by lysosomal hydrolases. Different intracellular parasites, exemplified here by Leishmania spp, Trypanosoma cruzi and Toxoplasma gondii, undermine host defences at each step by various strategies that ultimately ensure their targeting to, and survival in, an appropriate intracellular compartment.
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U2 - 10.1016/S0167-5699(05)80007-6
DO - 10.1016/S0167-5699(05)80007-6
M3 - Article
C2 - 2069674
AN - SCOPUS:0025833615
VL - 12
SP - A22-A27
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 3
ER -