TY - JOUR
T1 - Strategies for cyclizations of novel peptides on solid supports
AU - Hruby, Victor J.
AU - Wilke, Susanne
AU - Al-Obeidi, Fahad
AU - Jiao, Ding
AU - Lin, Ying
N1 - Funding Information:
This research was supported by grants from the U.S. Public Health Service DK 17420, DK 21085 and DK 36289.
PY - 1994/6
Y1 - 1994/6
N2 - Synthetic strategies and methods for the preparation of cyclic peptides on solid supports are very important for peptide synthesis in general, and for the preparation of conformationally constrained biologically active peptides. In this paper we report synthetic methods for the preparation on solid supports of the cyclic and bicyclic biologically active peptides, Ac-[Nle4, Asp5, d-Phe, Lys10]α-melanotropin(4-10)-NH2, [Lys17, Lys18, Asp21]glucagon-NH2, [β-Mpa1, Glu4, Cys6, Lys8]oxytocin and cyclo[GlyTrpNMeNleAspPhe] (cyclic CCK-5 analogue).
AB - Synthetic strategies and methods for the preparation of cyclic peptides on solid supports are very important for peptide synthesis in general, and for the preparation of conformationally constrained biologically active peptides. In this paper we report synthetic methods for the preparation on solid supports of the cyclic and bicyclic biologically active peptides, Ac-[Nle4, Asp5, d-Phe, Lys10]α-melanotropin(4-10)-NH2, [Lys17, Lys18, Asp21]glucagon-NH2, [β-Mpa1, Glu4, Cys6, Lys8]oxytocin and cyclo[GlyTrpNMeNleAspPhe] (cyclic CCK-5 analogue).
KW - Cyclic disulfides
KW - Cyclic lactams
KW - Cyclic peptides
KW - Cyclization of solid supports
KW - Cyclization on solid supports
KW - Orthogonal synthesis
KW - Solid-phase synthesis
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U2 - 10.1016/0923-1137(94)90121-X
DO - 10.1016/0923-1137(94)90121-X
M3 - Article
AN - SCOPUS:0028458187
SN - 0923-1137
VL - 22
SP - 231
EP - 241
JO - Reactive Polymers
JF - Reactive Polymers
IS - 3
ER -