Abstract
Asthma is a genetically complex disease with a multifaceted phenotype. Different approaches including population-based and family-based methods for evaluating genotype-phenotype relationships in asthma are discussed as well as the problems that may obscure these determinations. Examples of similar efforts in cystic fibrosis and breast cancer are considered in addition to interaction between causative genes and etiologically relevant environmental exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S482-S486 |
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 105 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2000 |
| Externally published | Yes |
Keywords
- Asthma
- Breast cancer
- Case-control study
- Complex disease
- Cystic fibrosis
- Gene-environment interaction
- Genotype
- Mendelian disease
- Phenotype
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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