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Stimulation of Rat Bladder Epithelial DNA Synthesis by Intravesical Instillation of Distilled Water

  • Seiichiro Ozono
  • , Ryoichi Oyasu
  • , in Chul Lee
  • , Ronald S. Weinstein

Research output: Contribution to journalArticlepeer-review

Abstract

Two commonly used cystoscopic infusion fluids were examined to determine whether their infusion stimulates DNA synthesis of the bladder epithelium. Following a single intravesical dose of 0.5 ml of distilled water or 1.5% L-glycine solution, rats were killed periodically up to 1 week. A transient but significant increase in epithelial cell [3H]thymidine labeling was observed at 48 hr after distilled water instillation. Glycine solution did not stimulate DNA synthesis.

Original languageEnglish (US)
Pages (from-to)325-327
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Volume182
Issue number3
DOIs
StatePublished - Jul 1986
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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