Stimulation of natural killer cell activity by murine retroviral infection and cocaine

Torka S. Poet; Radhakrishna Pillai; Steven Wood; Ronald Ross Watson

doi:10.1016/0378-4274(91)90066-F

Stimulation of natural killer cell activity by murine retroviral infection and cocaine

Torka S. Poet, Radhakrishna Pillai, Steven Wood, Ronald Ross Watson

Health Promotion Sciences

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12 Scopus citations

Abstract

The effects of cocaine and murine AIDS on natural killer (NK) cell activity in C57BL/6 mice was studied. Cocaine may play a major role in the development and progression to AIDS in the human population. Chronic intraperitoneal injection of cocaine was shown to cause an increase in NK cell activity over those of saline-treated animals. Infection with LP-BM5 murine leukemia retrovirus was also shown to increase NK cell activity. NK cell activity was increased in retrovirally infected mice treated with cocaine beyond that of mice treated with cocaine alone. This study indicates an important immunomodulatory effect of cocaine on NK cell activity, especially when combined with the effects caused by retroviral infection.

Original language	English (US)
Pages (from-to)	147-152
Number of pages	6
Journal	Toxicology letters
Volume	59
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-4274(91)90066-F
State	Published - Dec 1991

Keywords

Cocaine
Immunomodulation
LP-BM5 murine leukemia virus
Murine AIDS
Natural killer cell

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(91)90066-F

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title = "Stimulation of natural killer cell activity by murine retroviral infection and cocaine",

abstract = "The effects of cocaine and murine AIDS on natural killer (NK) cell activity in C57BL/6 mice was studied. Cocaine may play a major role in the development and progression to AIDS in the human population. Chronic intraperitoneal injection of cocaine was shown to cause an increase in NK cell activity over those of saline-treated animals. Infection with LP-BM5 murine leukemia retrovirus was also shown to increase NK cell activity. NK cell activity was increased in retrovirally infected mice treated with cocaine beyond that of mice treated with cocaine alone. This study indicates an important immunomodulatory effect of cocaine on NK cell activity, especially when combined with the effects caused by retroviral infection.",

keywords = "Cocaine, Immunomodulation, LP-BM5 murine leukemia virus, Murine AIDS, Natural killer cell",

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T1 - Stimulation of natural killer cell activity by murine retroviral infection and cocaine

AU - Poet, Torka S.

AU - Pillai, Radhakrishna

AU - Wood, Steven

AU - Watson, Ronald Ross

PY - 1991/12

Y1 - 1991/12

N2 - The effects of cocaine and murine AIDS on natural killer (NK) cell activity in C57BL/6 mice was studied. Cocaine may play a major role in the development and progression to AIDS in the human population. Chronic intraperitoneal injection of cocaine was shown to cause an increase in NK cell activity over those of saline-treated animals. Infection with LP-BM5 murine leukemia retrovirus was also shown to increase NK cell activity. NK cell activity was increased in retrovirally infected mice treated with cocaine beyond that of mice treated with cocaine alone. This study indicates an important immunomodulatory effect of cocaine on NK cell activity, especially when combined with the effects caused by retroviral infection.

AB - The effects of cocaine and murine AIDS on natural killer (NK) cell activity in C57BL/6 mice was studied. Cocaine may play a major role in the development and progression to AIDS in the human population. Chronic intraperitoneal injection of cocaine was shown to cause an increase in NK cell activity over those of saline-treated animals. Infection with LP-BM5 murine leukemia retrovirus was also shown to increase NK cell activity. NK cell activity was increased in retrovirally infected mice treated with cocaine beyond that of mice treated with cocaine alone. This study indicates an important immunomodulatory effect of cocaine on NK cell activity, especially when combined with the effects caused by retroviral infection.

KW - Cocaine

KW - Immunomodulation

KW - LP-BM5 murine leukemia virus

KW - Murine AIDS

KW - Natural killer cell

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Stimulation of natural killer cell activity by murine retroviral infection and cocaine

Abstract

Keywords

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