Stimulation of insulin-like growth factor-I production by recombinant bovine growth hormone in Mozambique tilapia, Oreochromis mossambicus

S. Kajimura, K. Uchida, T. Yada, L. G. Riley, J. C. Byatt, R. J. Collier, K. Aida, T. Hirano, E. G. Grau

    Research output: Contribution to journalArticlepeer-review

    62 Scopus citations

    Abstract

    We have previously reported growth-promoting effects of recombinant bovine growth hormone (rbGH) in Mozambique tilapia, Oreochromis mossambicus, after 4 weekly injections or a single injection of slow-releasing formulation (Posilac®) (Leedom et al. 2002). In order to obtain further understanding of the role of the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis in growth in the tilapia, the effects of rbGH on plasma and mRNA levels of IGF-I were examined. Plasma IGF-I levels were significantly increased after rbGH and Posilac® injections, and a significant correlation was observed between plasma IGF-I levels, body length and mass in both treatments. IGF-I mRNA levels in the liver and in the skeletal muscle were also significantly increased after rbGH and Posilac® injections, indicating that IGF-I gene expression in these tissues is under control of circulating GH. IGF-I mRNA levels in the gill were not affected by treatment. Liver IGF-I mRNA levels were significantly correlated with body length and with body mass after rbGH and Posilac® injections. These results indicate that the growth-promoting effect of rbGH in this species is mediated to a significant extent via its stimulation of hepatic production of IGF-I and the resulting increase in plasma IGF-I, and also possibly through locally produced IGF-I in the skeletal muscle, acting in a paracrine or autocrine fashion.

    Original languageEnglish (US)
    Pages (from-to)221-230
    Number of pages10
    JournalFish Physiology and Biochemistry
    Volume25
    Issue number3
    DOIs
    StatePublished - Dec 2001

    Keywords

    • Growth hormone
    • Insulin-like growth factor-I
    • Oreochromis mossambicus
    • RNase protection assay
    • Tilapia

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Aquatic Science

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