TY - JOUR
T1 - Stimulation by Gastric Inhibitory Polypeptide of Insulin and Glucagon Secretion by Rat Islet Cultures
AU - Fujimoto, Wilfred Y.
AU - Ensinck, John W.
AU - Merchant, Frederick W.
AU - Williams, Robert H.
AU - Smith, Phillip H.
AU - Johnson, David G.
N1 - Funding Information:
Supported in part by USPHS Grants AM02456, AM15312, AM16008, and AM17698, by the Kroc Foundation, by the Diabetes-Endocrinology Research Center (AM17047), and by the Washington Diabetes Association. Drs. Fujimoto and Johnson were recipients of Research Career Development Awards AM47142 and AM70727, respectively. Address reprint requests to Dr. Fujimoto at the Department of Medicine, RG-20, University of Washington, Seattle, Washington 98195. 1 1978 157 1 89 93
PY - 1978/1
Y1 - 1978/1
N2 - Physiologic amounts of GIP stimulated the secretion of IRI and IRG by monolayer cultures of neonatal rat pancreatic islets. Localization of exogenous GIP to a minority subpopulation of the islet cells was observed. The results may be interpreted to indicate that the effect of GIP on IRI release by the B cell is not direct, but rather, is mediated through its action on another islet cell type. Conversely, the action of GIP on IRG release may be directly mediated through an effect of GIP on the A cell. The action of GIP on IRG release apparently overrides any sup pressive effect that high glucose levels may exert. The stimulation by GIP of both IRI and IRG release was greater when a mixture of amino acids was omitted.
AB - Physiologic amounts of GIP stimulated the secretion of IRI and IRG by monolayer cultures of neonatal rat pancreatic islets. Localization of exogenous GIP to a minority subpopulation of the islet cells was observed. The results may be interpreted to indicate that the effect of GIP on IRI release by the B cell is not direct, but rather, is mediated through its action on another islet cell type. Conversely, the action of GIP on IRG release may be directly mediated through an effect of GIP on the A cell. The action of GIP on IRG release apparently overrides any sup pressive effect that high glucose levels may exert. The stimulation by GIP of both IRI and IRG release was greater when a mixture of amino acids was omitted.
UR - https://www.scopus.com/pages/publications/0018147364
UR - https://www.scopus.com/pages/publications/0018147364#tab=citedBy
U2 - 10.3181/00379727-157-39997
DO - 10.3181/00379727-157-39997
M3 - Article
C2 - 341178
AN - SCOPUS:0018147364
SN - 0037-9727
VL - 157
SP - 89
EP - 93
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
IS - 1
ER -