TY - JOUR
T1 - Still's-like innocent murmur can be produced by increasing aortic velocity to a threshold value
AU - Klewer, Scott E.
AU - Donnerstein, Richard L.
AU - Goldberg, Stanley J.
N1 - Funding Information:
From the Steele Memorial Children’s Research Center, University Heart Center, and the Department of Pediatrics (Cardiology), University of Arizona, College of Medicine, Tucson, Arizona. This study was supported by the Pediatric Cardiology Research Fund and the Cancer Research Fund, University of Arizona, College of Medicine, Tucson, Arizona, and by Grant T35HL07479 from the National Heart, Lung, and Blood Institute, Bethesda,M aryland. Manuscript received March 25, 1991;r evised manuscript received and acceptedM ay 23, 1991.
PY - 1991/9/15
Y1 - 1991/9/15
N2 - Still's murmur is a musical or vibratory systolic ejection murmur found in many normal school-aged children and adolescents. Its origin has been attributed to vibration of a cardiac structure during ventricular contraction, turbulent blood flow, or pressure changes across normal valves.1 We previously related Still's murmur to a small ascending aorta with concomitant high aortic velocity.2 Functional murmurs are accentuated in high cardiac output states such as fever, exercise and anemia. Dobutamine, a β1 agonist with primarily inotropic action at low doses, allows study of high cardiac output states. We investigated whether dobutamine infusion could produce a Stills-like murmur in subjects without murmurs at rest and evaluated those factors correlating best with murmur presence.
AB - Still's murmur is a musical or vibratory systolic ejection murmur found in many normal school-aged children and adolescents. Its origin has been attributed to vibration of a cardiac structure during ventricular contraction, turbulent blood flow, or pressure changes across normal valves.1 We previously related Still's murmur to a small ascending aorta with concomitant high aortic velocity.2 Functional murmurs are accentuated in high cardiac output states such as fever, exercise and anemia. Dobutamine, a β1 agonist with primarily inotropic action at low doses, allows study of high cardiac output states. We investigated whether dobutamine infusion could produce a Stills-like murmur in subjects without murmurs at rest and evaluated those factors correlating best with murmur presence.
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U2 - 10.1016/0002-9149(91)90664-7
DO - 10.1016/0002-9149(91)90664-7
M3 - Article
C2 - 1892096
AN - SCOPUS:0026009642
SN - 0002-9149
VL - 68
SP - 810
EP - 812
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 8
ER -