Steroid hormone receptor and COX-2 expression in chordoma

John H. Fasig, William D. Dupont, Sandra J. Olson, Bonnie J. LaFleur, Justin M.M. Cates

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Reports of sex steroid receptor expression in chordoma suggest that these tumors may be responsive to hormone manipulation therapy. Immunohistochemical stains for estrogen receptor (ER)-α, ER-β, progesterone receptor (PR), androgen receptor (AR), and cyclooxygenase 2 (COX-2), were performed on a tissue microarray containing 21 samples of chordoma. Most chordomas expressed COX-2, ER-β, and AR, whereas ER-α and PR stains were negative in all cases. ER-β expression did not correlate with AR expression (P = .4142; McNemar test). There were no statistically significant correlations between the expression of any of these markers and anatomic location of tumor, patient sex, patient age, or disease-free survival. Chordomas commonly express COX-2, AR, and ER-β. These findings may have therapeutic implications concerning the use of agents that inhibit or modulate these signaling molecules.

Original languageEnglish (US)
Pages (from-to)375-381
Number of pages7
JournalAmerican journal of clinical pathology
Volume128
Issue number3
DOIs
StatePublished - Sep 2007
Externally publishedYes

Keywords

  • Androgen receptor
  • Chordoma
  • COX-2
  • Cyclooxygenase-2
  • Estrogen receptor
  • Steroid hormone receptors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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